Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_8
Snippet: DENV MTase is located on the N-terminus of NS5 and catalyzes the N-7 and 2 -O methylations of the viral RNA cap [19] . These modifications are necessary for formation of the mature RNA cap structure. The MTase uses Sadenosylmethionine (SAM) as the methylating cofactor. There are binding sites for GTP and the guanine moiety of the RNA cap (the GTP pocket) and for SAM. DENV MTase is a valid antiviral target, and the GTP binding site has been identi.....
Document: DENV MTase is located on the N-terminus of NS5 and catalyzes the N-7 and 2 -O methylations of the viral RNA cap [19] . These modifications are necessary for formation of the mature RNA cap structure. The MTase uses Sadenosylmethionine (SAM) as the methylating cofactor. There are binding sites for GTP and the guanine moiety of the RNA cap (the GTP pocket) and for SAM. DENV MTase is a valid antiviral target, and the GTP binding site has been identified as a valid site for development of antivirals [20] . Although S-adenosylmethionine associates tightly with DENV MTase and displacement of SAM may be difficult, the SAM binding site may, however, be capable of binding other ligands [12, 21] .
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