Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_4
Snippet: DENV protease (NS2B-NS3pro) is a trypsin-like serine protease that cleaves the dengue polyprotein into individual proteins necessary for viral replication. DENV protease has been identified as a primary target for the development of dengue antiviral drugs [15] . There are two potential targets for DENV protease inhibition: (1) the active site of the protease [16] , and (2) block association of NS3pro with its protein cofactor NS2B [17] ......
Document: DENV protease (NS2B-NS3pro) is a trypsin-like serine protease that cleaves the dengue polyprotein into individual proteins necessary for viral replication. DENV protease has been identified as a primary target for the development of dengue antiviral drugs [15] . There are two potential targets for DENV protease inhibition: (1) the active site of the protease [16] , and (2) block association of NS3pro with its protein cofactor NS2B [17] .
Search related documents:
Co phrase search for related documents- active site and dengue polyprotein: 1
- active site and DENV protease: 1, 2, 3, 4, 5, 6, 7
- active site and potential target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- active site and primary target: 1, 2
- active site and protein cofactor: 1, 2
- active site and serine protease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31
- active site and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- antiviral drug and dengue antiviral drug: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral drug and DENV protease: 1, 2
- antiviral drug and potential target: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51
- antiviral drug and primary target: 1, 2, 3, 4, 5, 6, 7, 8
- antiviral drug and serine protease: 1, 2, 3, 4, 5, 6, 7
- antiviral drug and viral replication: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- dengue antiviral drug and viral replication: 1
- DENV protease and serine protease: 1, 2, 3, 4
- DENV protease and viral replication: 1, 2, 3
- individual protein and potential target: 1, 2
- individual protein and primary target: 1, 2
- individual protein and viral replication: 1, 2, 3, 4, 5, 6, 7, 8
Co phrase search for related documents, hyperlinks ordered by date