Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_4
Snippet: DENV protease (NS2B-NS3pro) is a trypsin-like serine protease that cleaves the dengue polyprotein into individual proteins necessary for viral replication. DENV protease has been identified as a primary target for the development of dengue antiviral drugs [15] . There are two potential targets for DENV protease inhibition: (1) the active site of the protease [16] , and (2) block association of NS3pro with its protein cofactor NS2B [17] ......
Document: DENV protease (NS2B-NS3pro) is a trypsin-like serine protease that cleaves the dengue polyprotein into individual proteins necessary for viral replication. DENV protease has been identified as a primary target for the development of dengue antiviral drugs [15] . There are two potential targets for DENV protease inhibition: (1) the active site of the protease [16] , and (2) block association of NS3pro with its protein cofactor NS2B [17] .
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