Selected article for: "Ã1 frameshifting and Ã1 frameshifting"
Author: Henderson, Clark M.; Anderson, Christine B.; Howard, Michael T.
Title: Antisense-induced ribosomal frameshifting
  • Document date: 2006_8_18
    • ID: xgwbl8em_37
    Snippet: The ability of antisense oligonucleotides to induce highlevel À1 frameshifting (29, 30) demonstrates that elaborate tertiary structures are not required, and that a duplex formed by complementary antisense oligonucleotides (with a variety of chemistries, including RNA, 2 0 -O-Methyl, morpholino) is sufficient to induce high-level frameshifting. Here we demonstrate for the first time that trans-acting antisense oligonucleotides may stimulate ribo.....
    Document: The ability of antisense oligonucleotides to induce highlevel À1 frameshifting (29, 30) demonstrates that elaborate tertiary structures are not required, and that a duplex formed by complementary antisense oligonucleotides (with a variety of chemistries, including RNA, 2 0 -O-Methyl, morpholino) is sufficient to induce high-level frameshifting. Here we demonstrate for the first time that trans-acting antisense oligonucleotides may stimulate ribosome shifting to the +1 reading frame at surprisingly high levels, levels which are greater than those achieved by natural 3 0 cis-acting mRNA pseudoknot structures in programmed +1 frameshifting.

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