Author: Bederka, Lydia H.; Bonhomme, Cyrille J.; Ling, Emily L.; Buchmeier, Michael J.
Title: Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization Document date: 2014_10_28
ID: wbh06gzb_14
Snippet: We used flow cytometry to measure surface expression of each FLLL mutant glycoprotein (Fig. 5B ). Only the FALA GPC and the YALL GPC mutants resulted in glycoprotein detection above mock transfection levels, although these two mutants had more than a 50% reduction in GP1 signal compared to that of WT GPC, indicating that fusion activity and plasma membrane trafficking are both affected by mutations within SSP......
Document: We used flow cytometry to measure surface expression of each FLLL mutant glycoprotein (Fig. 5B ). Only the FALA GPC and the YALL GPC mutants resulted in glycoprotein detection above mock transfection levels, although these two mutants had more than a 50% reduction in GP1 signal compared to that of WT GPC, indicating that fusion activity and plasma membrane trafficking are both affected by mutations within SSP.
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