Author: Powers, Chelsea N.; Setzer, William N.
Title: An In-Silico Investigation of Phytochemicals as Antiviral Agents Against Dengue Fever Document date: 2016_8_23
ID: q7thhtg3_38
Snippet: A number of flavonoids from Silybum marianum have shown exceptional docking to the hydrophobic pore of DENV Ep (2,3-dehydroxilybin, cisilandrin, isosilybins A-D, silandrins A-B, and silybin ( Table 5) . Silybin (silibinin, silymarin) has shown antiviral activity against hepatitis C virus [63] and chikungunya virus [64] . C-geranylated flavanones from Paulownia tomentosa fruits have shown antibacterial [65, 66] , cytotoxic [67] , and anti-inflamma.....
Document: A number of flavonoids from Silybum marianum have shown exceptional docking to the hydrophobic pore of DENV Ep (2,3-dehydroxilybin, cisilandrin, isosilybins A-D, silandrins A-B, and silybin ( Table 5) . Silybin (silibinin, silymarin) has shown antiviral activity against hepatitis C virus [63] and chikungunya virus [64] . C-geranylated flavanones from Paulownia tomentosa fruits have shown antibacterial [65, 66] , cytotoxic [67] , and anti-inflammatory [68] activities as well as SARS-CoV protease inhibitory activity [69] . Diplacone showed excellent docking properties with DENV MTase ( Table 3) and both 3 -O-methyldiplacone and 3 -O-methyldiplacol docked well with the ATP site of DENV helicase ( Table 2) . Diplacone, bonannione A, 3 -Omethyldiplacone and 4 -O-methyldiplacone docked well with the hydrophobic channel of DENV Ep (Table 5) . Likewise, the C-geranylated flavone cannflavin A, from Cannabis sativa [70] , also docked well with DENV Ep ( Table 5) .
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