Selected article for: "mrnas sequence contain and sequence contain"
Author: Zirkel, Florian; Kurth, Andreas; Quan, Phenix-Lan; Briese, Thomas; Ellerbrok, Heinz; Pauli, Georg; Leendertz, Fabian H.; Lipkin, W. Ian; Ziebuhr, John; Drosten, Christian; Junglen, Sandra
Title: An Insect Nidovirus Emerging from a Primary Tropical Rainforest
  • Document date: 2011_6_14
    • ID: ulwo6i38_13
    Snippet: Regulation of transcription. Although all nidovirus subgenomic mRNAs are 3= coterminal, different families and genera have different subgenomic mRNA 5= ends. ArV and CoV subgenomic mRNAs contain a common 5= leader sequence derived from the 5= terminus of the genomic RNA. The leader template is fused to nascent minus strand mRNA templates via a copy choicerelated template switching process called discontinuous extension of minus strands or discont.....
    Document: Regulation of transcription. Although all nidovirus subgenomic mRNAs are 3= coterminal, different families and genera have different subgenomic mRNA 5= ends. ArV and CoV subgenomic mRNAs contain a common 5= leader sequence derived from the 5= terminus of the genomic RNA. The leader template is fused to nascent minus strand mRNA templates via a copy choicerelated template switching process called discontinuous extension of minus strands or discontinuous transcription (DT) (47, 48) . Copy choice occurs at transcription-regulating sequences (TRS), comprising short conserved sequence motifs that follow the leader and precede each downstream gene's ORF (48) (49) (50) . In contrast, the subgenomic mRNAs of RoV do not contain leader sequences (24) . Synthesis of subgenomic mRNA templates is believed to be mediated solely by attenuation of minus strand synthesis, involving mRNA transcription on minus-stranded replicative intermediates (nondiscontinuous transcription [NDT]) (26) . ToV uses DT to express RNA2 and NDT for RNAs 3 through 5, respectively (51) .

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