Selected article for: "calcium signaling and oxidative stress"
Author: Zhang, Fen; Liu, Chang; Wang, Lei; Cao, Xi; Wang, Ying Ying; Yang, Jin Kui
Title: Antioxidant effect of angiotensin (1-7) in the protection of pancreatic ß cell function
  • Document date: 2016_7_13
    • ID: xndjru4d_22
    Snippet: The present study demonstrated that Ang (1-7) can partially restore insulin secretion from INS-1 cells (which is reduced by oxidative stress injury) and reduce the level of intracellular ROS. This protective effect was associated with the change in cellular calcium signaling and mitochondrial function. Ang (1-7) can restore early phase calcium signaling and mitochondrial membrane potential, and has a protective effect on mitochondrial function; h.....
    Document: The present study demonstrated that Ang (1-7) can partially restore insulin secretion from INS-1 cells (which is reduced by oxidative stress injury) and reduce the level of intracellular ROS. This protective effect was associated with the change in cellular calcium signaling and mitochondrial function. Ang (1-7) can restore early phase calcium signaling and mitochondrial membrane potential, and has a protective effect on mitochondrial function; however, Ang-(1-7) protective effects could be blockaded by its specific inhibitor, A779. To the best of our knowledge, this is the first study to confirm the antioxidant effect of Ang (1-7) in INS-1 β cells.

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