Selected article for: "Î cell and insulin secretion"
Author: Zhang, Fen; Liu, Chang; Wang, Lei; Cao, Xi; Wang, Ying Ying; Yang, Jin Kui
Title: Antioxidant effect of angiotensin (1-7) in the protection of pancreatic ß cell function
  • Document date: 2016_7_13
    • ID: xndjru4d_28
    Snippet: In conclusion, to the best of our knowledge, the present study was the first to demonstrate the antioxidant effect of Ang (1) (2) (3) (4) (5) (6) (7) in the INS-1 pancreatic cell line and the restorative effects of Ang (1-7) on insulin secretion. This was associated with restoration of calcium signaling, reduction of ROS generation and restoration of the impaired mitochondrial function in oxidative stress conditions. The effects observed followin.....
    Document: In conclusion, to the best of our knowledge, the present study was the first to demonstrate the antioxidant effect of Ang (1) (2) (3) (4) (5) (6) (7) in the INS-1 pancreatic cell line and the restorative effects of Ang (1-7) on insulin secretion. This was associated with restoration of calcium signaling, reduction of ROS generation and restoration of the impaired mitochondrial function in oxidative stress conditions. The effects observed following treatment with Ang (1-7) were inhibited by its specific antagonist, A779. This study demonstrated that reducing ROS production and restoring mitochondrial function are likely to be the mechanisms underlying the protective effects of Ang (1-7) on pancreatic β cell function under oxidative stress. Notably, this experiment confirms the importance of Ang (1-7) in the early stages of diabetes. These findings may assist with the treatment of diabetes in future, potentially during the development of novel therapeutic strategies.

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