Selected article for: "FLLL motif and functional glycoprotein"
Author: Bederka, Lydia H.; Bonhomme, Cyrille J.; Ling, Emily L.; Buchmeier, Michael J.
Title: Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization
  • Document date: 2014_10_28
    • ID: wbh06gzb_4
    Snippet: Our current studies focus on the importance of SSP in terms of nascent glycoprotein complex expression, maturation, and function. Using Western blot analysis, confocal microscopy, and flow cytometry, we show that LCMV GP lacking the native SSP does not exit the endoplasmic reticulum or mature through the secretory pathway. We detect SSP at the plasma membrane, and mutations within SSP affect trafficking of the entire glycoprotein complex. Further.....
    Document: Our current studies focus on the importance of SSP in terms of nascent glycoprotein complex expression, maturation, and function. Using Western blot analysis, confocal microscopy, and flow cytometry, we show that LCMV GP lacking the native SSP does not exit the endoplasmic reticulum or mature through the secretory pathway. We detect SSP at the plasma membrane, and mutations within SSP affect trafficking of the entire glycoprotein complex. Further, we define a conserved FLLL motif within the LCMV SSP that is the driving force for full-length and functional maturation and glycoprotein subunit association.

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