Author: Bederka, Lydia H.; Bonhomme, Cyrille J.; Ling, Emily L.; Buchmeier, Michael J.
Title: Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization Document date: 2014_10_28
ID: wbh06gzb_4
Snippet: Our current studies focus on the importance of SSP in terms of nascent glycoprotein complex expression, maturation, and function. Using Western blot analysis, confocal microscopy, and flow cytometry, we show that LCMV GP lacking the native SSP does not exit the endoplasmic reticulum or mature through the secretory pathway. We detect SSP at the plasma membrane, and mutations within SSP affect trafficking of the entire glycoprotein complex. Further.....
Document: Our current studies focus on the importance of SSP in terms of nascent glycoprotein complex expression, maturation, and function. Using Western blot analysis, confocal microscopy, and flow cytometry, we show that LCMV GP lacking the native SSP does not exit the endoplasmic reticulum or mature through the secretory pathway. We detect SSP at the plasma membrane, and mutations within SSP affect trafficking of the entire glycoprotein complex. Further, we define a conserved FLLL motif within the LCMV SSP that is the driving force for full-length and functional maturation and glycoprotein subunit association.
Search related documents:
Co phrase search for related documents- complex expression and current study: 1, 2
- complex expression and endoplasmic reticulum: 1, 2, 3
- complex expression and FLLL motif: 1
- complex expression and flow cytometry: 1, 2, 3, 4, 5, 6, 7, 8, 9
- complex expression and function maturation: 1
- complex expression and glycoprotein complex: 1, 2, 3, 4, 5, 6
- complex expression and plasma membrane: 1, 2, 3
- complex expression and secretory pathway: 1
- complex expression and western blot: 1, 2, 3, 4, 5, 6, 7, 8
- complex expression and western blot analysis: 1
- confocal microscopy and current study: 1, 2, 3, 4, 5, 6
- confocal microscopy and endoplasmic reticulum: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33
- confocal microscopy and FLLL motif: 1, 2
- confocal microscopy and flow cytometry: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51
- confocal microscopy and flow cytometry confocal microscopy: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36
- confocal microscopy and functional maturation: 1
- confocal microscopy and glycoprotein complex: 1, 2, 3, 4
- confocal microscopy and LCMV ssp: 1, 2
- confocal microscopy and plasma membrane: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
Co phrase search for related documents, hyperlinks ordered by date