Selected article for: "HEL rdrp and helicase domain"
Author: Zirkel, Florian; Kurth, Andreas; Quan, Phenix-Lan; Briese, Thomas; Ellerbrok, Heinz; Pauli, Georg; Leendertz, Fabian H.; Lipkin, W. Ian; Ziebuhr, John; Drosten, Christian; Junglen, Sandra
Title: An Insect Nidovirus Emerging from a Primary Tropical Rainforest
  • Document date: 2011_6_14
    • ID: ulwo6i38_11
    Snippet: Putative replicase polyprotein genes. The replicase genes of nidoviruses share several domains and features conserved across the families Arteriviridae, Coronaviridae, and Roniviridae (25) . These are (from the N to the C terminus) transmembrane domain 1 (TMD1), TMD2, a 3C-like protease (3CL pro ) (31), TMD3, a ribosomal frameshift site (RFS) (32, 33) , an RNA-dependent RNA polymerase (RdRp) (34), a zinc-binding domain (ZBD), an RNA helicase (HEL.....
    Document: Putative replicase polyprotein genes. The replicase genes of nidoviruses share several domains and features conserved across the families Arteriviridae, Coronaviridae, and Roniviridae (25) . These are (from the N to the C terminus) transmembrane domain 1 (TMD1), TMD2, a 3C-like protease (3CL pro ) (31), TMD3, a ribosomal frameshift site (RFS) (32, 33) , an RNA-dependent RNA polymerase (RdRp) (34), a zinc-binding domain (ZBD), an RNA helicase (HEL), and a uridylate-specific endoribonuclease (Nen-doU) (35, 36) . CoV, ToV, and RoV also share a 3=-5= exonuclease (ExoN) upstream of NendoU (37) and a ribose-2=-Omethyltransferase (MT) at the C terminus (38, 39) . CoV and ToV also encode an ADP-ribose 1-phosphatase upstream of TMD1 (19, 40, 41) .

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