Selected article for: "MERS cov and transmission process"
Author: Park, Donghyun; Huh, Hee Jae; Kim, Yeon Jeong; Son, Dae-Soon; Jeon, Hyo-Jeong; Im, Eu-Hyun; Kim, Jong-Won; Lee, Nam Yong; Kang, Eun-Suk; Kang, Cheol In; Chung, Doo Ryeon; Ahn, Jin-Hyun; Peck, Kyong Ran; Choi, Sun Shim; Kim, Yae-Jean; Ki, Chang-Seok; Park, Woong-Yang
Title: Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus
  • Document date: 2016_11_23
    • ID: xgp2vx6o_24
    Snippet: Because the evolution of a virus is a continuous process that takes place during intrapatient infection and interpatient transmission, the evolution of MERS-CoVs should be studied at both intra-and interpatient levels to obtain a better understanding of the principles underlying the complex molecular evolution of MERS-CoVs in natural populations. However, our knowledge of MERS-CoV evolution primarily depends on analysis at the interpatient level,.....
    Document: Because the evolution of a virus is a continuous process that takes place during intrapatient infection and interpatient transmission, the evolution of MERS-CoVs should be studied at both intra-and interpatient levels to obtain a better understanding of the principles underlying the complex molecular evolution of MERS-CoVs in natural populations. However, our knowledge of MERS-CoV evolution primarily depends on analysis at the interpatient level, ignoring genetic diversity within individual patients. In this study, we demonstrated intrapatient heterogeneity in human MERS-CoV isolates. Based on the analyses of the genetic diversity of MERS-CoVs at both the intra-and interpatient levels, our results shed light on the evolutionary dynamics of MERS-CoVs associated with the South Korean outbreak.

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