Author: Sievers, Stuart A.; Scharf, Louise; West, Anthony P.; Bjorkman, Pamela J.
Title: Antibody engineering for increased potency, breadth and half-life Document date: 2015_4_15
ID: zer0u60z_23
Snippet: In addition to traditional IgG architectures (Fig. 2a) , other scaffolds have been used to achieve bispecific recognition. Small molecules can be conjugated to IgGs to create bifunctional reagents (Fig. 2b) ; for example conjugating cholesterol to the light chains of the anti-MPER bNAbs 2F5 and D5 enhanced their potencies through cholesterol-mediated interactions with the viral membrane [99] . In another study, a small-molecule inhibitor of viral.....
Document: In addition to traditional IgG architectures (Fig. 2a) , other scaffolds have been used to achieve bispecific recognition. Small molecules can be conjugated to IgGs to create bifunctional reagents (Fig. 2b) ; for example conjugating cholesterol to the light chains of the anti-MPER bNAbs 2F5 and D5 enhanced their potencies through cholesterol-mediated interactions with the viral membrane [99] . In another study, a small-molecule inhibitor of viral entry, aplaviroc, was conjugated to the Fc to enhance neutralization potency [100] .
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