Selected article for: "korean outbreak and MERS cov"
Author: Park, Donghyun; Huh, Hee Jae; Kim, Yeon Jeong; Son, Dae-Soon; Jeon, Hyo-Jeong; Im, Eu-Hyun; Kim, Jong-Won; Lee, Nam Yong; Kang, Eun-Suk; Kang, Cheol In; Chung, Doo Ryeon; Ahn, Jin-Hyun; Peck, Kyong Ran; Choi, Sun Shim; Kim, Yae-Jean; Ki, Chang-Seok; Park, Woong-Yang
Title: Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus
  • Document date: 2016_11_23
    • ID: xgp2vx6o_3
    Snippet: To date, no intrahost MERS-CoV single-nucleotide variants have been identified in humans, except by Cotton et al. (2013a) , where data from one specimen showed the presence of non-consensus variants (<5%). Currently, it is hard to discern whether only consensus sequences have been reported or whether human MERS-CoV sequences represent almost clonal virus populations within individual cases. By analyzing non-consensus sequences in 35 specimens fro.....
    Document: To date, no intrahost MERS-CoV single-nucleotide variants have been identified in humans, except by Cotton et al. (2013a) , where data from one specimen showed the presence of non-consensus variants (<5%). Currently, it is hard to discern whether only consensus sequences have been reported or whether human MERS-CoV sequences represent almost clonal virus populations within individual cases. By analyzing non-consensus sequences in 35 specimens from 24 patients infected during the South Korean outbreak (2015), we demonstrated the existence of intrapatient heterogeneity and investigated its functional implications.

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