Author: Yamashita, Masamichi
Title: Aspirin Intolerance: Experimental Models for Bed-to-Bench Document date: 2016_12_23
ID: ry6xr4ix_38
Snippet: Salicylic acid (Fig. 1f) is secreted by plants in response to pathogens and induces resistance to viruses [77] . The salicylate receptors in plants are nonexpressors of PR gene 1 (NPR1), which is a homolog of IκB in mammals [78] , and has NPR1-like proteins 3, and 4 as paralogues [79, 80] . In tumor necrosis factor-treated COS-1 cells, it has been demonstrated that sodium salicylate (1-20 mM) inhibits the degradation of IκBα, but not IκBβ, v.....
Document: Salicylic acid (Fig. 1f) is secreted by plants in response to pathogens and induces resistance to viruses [77] . The salicylate receptors in plants are nonexpressors of PR gene 1 (NPR1), which is a homolog of IκB in mammals [78] , and has NPR1-like proteins 3, and 4 as paralogues [79, 80] . In tumor necrosis factor-treated COS-1 cells, it has been demonstrated that sodium salicylate (1-20 mM) inhibits the degradation of IκBα, but not IκBβ, via inhibition of IκB kinase activity [81, 82] .
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