Antimicrobial activity of novel synthesized coumarin based transitional metal complexes

Sahoo, Jyotirmaya; Paidesetty, Sudhir K.

The results of the antimicrobial activity of the newly synthesized 3-aryl-azo-4-hydroxy coumarin analogues and their complexes compared with reference antibiotics (RA) ampicillin and fluconazole (as antibacterial and antifungal standard drugs, respectively) expressed in mean AE SD are reported in Table 2 . The reported results revealed that compounds 4a and 4e showed significant antimicrobial activity in comparison to standard drugs (p < 0.05) against E. coli, K. pneumonia, S. aureus, C. albicans and C. neoformans. All compounds except for 4d and 4h showed significant antibacterial activity against S. aureus. However, complex 4a showed highest mean zone of inhibition (mm) against K. pneumonia and C. neoformans, 19 AE 1.1 and 27.5 AE 1.64, respectively. The largest mean zones of inhibition exhibited by complex 4e against S. aureus and C. neoformans was 23 AE 2.28 and 28.17 AE 1.72, respectively. The anti-biogram pattern of compound 3a, 3b and their complexes against different fungal strains are illustrated in Figure 6 . The graphical representation of complexes 4a and 4e is illustrated in Figure 7 .