Author: Zhang, Fen; Liu, Chang; Wang, Lei; Cao, Xi; Wang, Ying Ying; Yang, Jin Kui
Title: Antioxidant effect of angiotensin (1-7) in the protection of pancreatic ß cell function Document date: 2016_7_13
ID: xndjru4d_3
Snippet: Oxidative stress is one of the most important factors in β cell loss (20) . However, little is known regarding the correlation between Ang (1-7) and oxidative stress in the pancreas. In the present study, the protective effect of Ang (1-7) on oxidative β cell damage was investigated. The protective effect was shown to occur by improving GSIS, glucose stimulated calcium (GSCa) responses and the mitochondrial membrane potential (MMP), which was d.....
Document: Oxidative stress is one of the most important factors in β cell loss (20) . However, little is known regarding the correlation between Ang (1-7) and oxidative stress in the pancreas. In the present study, the protective effect of Ang (1-7) on oxidative β cell damage was investigated. The protective effect was shown to occur by improving GSIS, glucose stimulated calcium (GSCa) responses and the mitochondrial membrane potential (MMP), which was demonstrated previously (21) , and reducing the production of reactive oxygen species (ROS). The selective receptor antagonist A779 was used to confirm the protective role of Ang (1-7).
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