Author: Bederka, Lydia H.; Bonhomme, Cyrille J.; Ling, Emily L.; Buchmeier, Michael J.
Title: Arenavirus Stable Signal Peptide Is the Keystone Subunit for Glycoprotein Complex Organization Document date: 2014_10_28
ID: wbh06gzb_27
Snippet: Immunoprecipitation of both the SSP and the GP1 subunits revealed that SSP is the subunit that stabilizes the organization of the trimeric glycoprotein complex. Whole-genome small interfering RNA (siRNA) screens have implicated the involvement of the COP1 subunit for LCMV infection (49) . Furthermore, proteomic analysis led to the identification of ERGIC-53 as a host factor involved in the production of infectious particles (50) . Future experime.....
Document: Immunoprecipitation of both the SSP and the GP1 subunits revealed that SSP is the subunit that stabilizes the organization of the trimeric glycoprotein complex. Whole-genome small interfering RNA (siRNA) screens have implicated the involvement of the COP1 subunit for LCMV infection (49) . Furthermore, proteomic analysis led to the identification of ERGIC-53 as a host factor involved in the production of infectious particles (50) . Future experiments using the tools presented here may allow for the identification of host proteins that interact with SSP. A deeper understanding of the mechanism by which this family of viruses involves host pathways would define targets for antiviral therapeutics.
Search related documents:
Co phrase search for related documents- antiviral therapeutic and glycoprotein complex: 1
- antiviral therapeutic and host factor: 1, 2, 3, 4, 5
- antiviral therapeutic and host pathway: 1, 2, 3
- antiviral therapeutic and host protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- antiviral therapeutic target and host pathway: 1
- antiviral therapeutic target and host protein: 1, 2, 3, 4
- deep understanding and host protein: 1, 2, 3
- deep understanding and present tool: 1
- glycoprotein complex and GP1 subunit: 1, 2, 3, 4, 5, 6, 7, 8
- glycoprotein complex and host factor: 1
- glycoprotein complex and host protein: 1, 2
- glycoprotein complex and infectious particle: 1
- host factor and infectious particle: 1, 2
- host factor and proteomic analysis: 1, 2
- host protein and infectious particle: 1
- host protein and LCMV infection: 1, 2
- host protein and proteomic analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- infectious particle and proteomic analysis: 1
- present tool and proteomic analysis: 1
Co phrase search for related documents, hyperlinks ordered by date