Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_186
Snippet: Compared to the normal tissues, the number of intratumoral and peritumoral Tregs in the tumor tissues were significantly increased in dogs with squamous cell carcinoma (P < 0.0001), oral malignant melanoma (P < 0.0001), lung adenocarcinoma (P < 0.0001), and transitional cell carcinoma (P < 0.0001). No significant difference was observed in Foxp3-positive Tregs between normal liver and hepatocellular carcinoma. The overall survival for cases with .....
Document: Compared to the normal tissues, the number of intratumoral and peritumoral Tregs in the tumor tissues were significantly increased in dogs with squamous cell carcinoma (P < 0.0001), oral malignant melanoma (P < 0.0001), lung adenocarcinoma (P < 0.0001), and transitional cell carcinoma (P < 0.0001). No significant difference was observed in Foxp3-positive Tregs between normal liver and hepatocellular carcinoma. The overall survival for cases with a high number of intratumoral Tregs was significantly shorter than for cases with a low number of intratumoral Tregs in dogs with lung adenocarcinoma (P = 0.0074), squamous cell carcinoma (P = 0.0145), and transitional cell carcinoma (P = 0.0011). In dogs with hepatocellular carcinoma and oral malignant melanoma, the number of Foxp3-positive Tregs was not significantly related to the prognosis.
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