2017 ACVIM Forum Research Abstract Program

This study demonstrated that Foxp3-positive Tregs infiltrated into various canine tumor tissues. The higher number of intratumoral Tregs was associated with negative outcomes in dogs with lung adenocarcinoma, squamous cell carcinoma, and transitional cell carcinoma, suggesting that tumor-infiltrating Tregs contribute to the suppression of antitumor immunity in dogs as well as in humans. Osteosarcoma is the most common primary bone malignancy in the dog. Based on favorable findings in infected canine limb-spare patients, stagnant survival times despite a plethora of adjuvant chemotherapy options, and promising recent preclinical and human immunotherapy outcomes, novel immunotherapy approaches have become attractive treatment options.