Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_200
Snippet: These findings demonstrate that PD-L1 is variably expressed in canine DLBCL, and that higher expression of PD-L1 correlates with reduced PFS in affected dogs. Introduction: Monocarboxylate transporters (MCT) transport lactic acid across plasma membranes, providing a mechanism for tumor cells to meet their bioenergetic needs during glycolysis in a variety of microenvironments. The objective of this work is to explore the therapeutic potential of m.....
Document: These findings demonstrate that PD-L1 is variably expressed in canine DLBCL, and that higher expression of PD-L1 correlates with reduced PFS in affected dogs. Introduction: Monocarboxylate transporters (MCT) transport lactic acid across plasma membranes, providing a mechanism for tumor cells to meet their bioenergetic needs during glycolysis in a variety of microenvironments. The objective of this work is to explore the therapeutic potential of modulating cellular metabolism through inhibition of MCT1 and MCT4 in canine osteosarcoma, with the ultimate goal of providing proof of principle data to support future clinical studies.
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