2017 ACVIM Forum Research Abstract Program

Recently-diagnosed diabetic cats (duration 6 weeks -5 months) were recruited through a dedicated feline DM clinic. Cats were transitioned to a low-carbohydrate diet 10 days before first examination, with overweight cats (body condition score >5/9) receiving caloric intake aimed at weight loss. Cats were excluded if prerecruitment screening identified ketoacidosis, clinical pancreatitis, glucocorticoid/progestogen administration, hyperthyroidism, hypersomatotropism, or other conditions causing likely insulin resistance. Diabetic control was assessed using fructosamine, a validated diabetic clinical score (DCS), mean blood glucose (MBG) during 24-hour blood glucose curves (BGCs) and twice-daily (BID) insulin dose (U/kg). Pet and owner quality of life was assessed using the validated DIAQoL-pet score. Cats were randomized to receive BID glargine or PZIR and underwent a oneyear, standardized re-examination program. Insulin dose was adjusted according to a single, nadir-led protocol based on BGC results.