2017 ACVIM Forum Research Abstract Program

Twenty-two cases of biopsy-confirmed PU were identified (mean age 8 years; range 1-15 years). There were 14 females, 8 males, and 15 breeds represented. Four dogs had positive ABUC perioperatively, 4 had positive mucosal bacterial cultures, and 11 had negative ABUC. Urine cultures were unavailable or not performed in 7 dogs. FISH analysis was performed in 13 cases; adherent/invasive bacteria were noted in 5 dogs, and tissue-associated bacteria in 2 dogs. Of these 7 dogs, 3 had positive ABUC at the time of biopsy. The 6 FISH analyses that were negative for bacteria also had negative ABUC. One of the dogs with adherent/invasive bacteria visualized had lymphoplasmacytic and histiocytic urethritis; the remaining 12 had neutrophilic, lymphoplasmacytic, or mixed inflammation reported on histopathology. These results suggest that primary or secondary bacterial invasion may be associated with PU, despite negative ABUC; this knowledge may alter treatment of this disease. The aim of this study was to measure vitamin D metabolites in dogs with and without a history of CaOx urolithiasis.