Selected article for: "disorder content and intrinsic disorder content"
Author: Rahaman, Jordon; Siltberg-Liberles, Jessica
Title: Avoiding Regions Symptomatic of Conformational and Functional Flexibility to Identify Antiviral Targets in Current and Future Coronaviruses
  • Document date: 2016_11_9
    • ID: pygykil7_39
    Snippet: Furthermore, based on the inconsistent prediction of secondary structure elements, the possibility that CoVs are more conformationally flexible than their intrinsic disorder content implies is noteworthy. Altogether, this suggests that various mechanisms for rewiring conformational and functional space are operating in the coronaviruses studied here. If regions symptomatic of conformational and functional flexibility can be avoided in order to id.....
    Document: Furthermore, based on the inconsistent prediction of secondary structure elements, the possibility that CoVs are more conformationally flexible than their intrinsic disorder content implies is noteworthy. Altogether, this suggests that various mechanisms for rewiring conformational and functional space are operating in the coronaviruses studied here. If regions symptomatic of conformational and functional flexibility can be avoided in order to identify broad-specificity antiviral targets with potential to be effective against coronaviruses of today and in the future, coronaviruses as a group may become more attractive drug targets for the pharmaceutical industry in the event an additional coronavirus changes host to include humans or increase its virulence.

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