Author: Zhou, Haixia; Zhao, Jincun; Perlman, Stanley
Title: Autocrine Interferon Priming in Macrophages but Not Dendritic Cells Results in Enhanced Cytokine and Chemokine Production after Coronavirus Infection Document date: 2010_10_19
ID: qg541qho_2
Snippet: Both macrophages, in which IFN is induced, and DC, in which IFN is not induced, are important target cells for several coronaviruses. DC in particular are critical for initiation of the antivirus T-and B-cell responses, which are ultimately critical for virus clearance. Infection of DC and macrophages likely contributes to the development of effective innate and adaptive immune responses, but macrophage infection, in the case of some coronaviruse.....
Document: Both macrophages, in which IFN is induced, and DC, in which IFN is not induced, are important target cells for several coronaviruses. DC in particular are critical for initiation of the antivirus T-and B-cell responses, which are ultimately critical for virus clearance. Infection of DC and macrophages likely contributes to the development of effective innate and adaptive immune responses, but macrophage infection, in the case of some coronaviruses, also contributes to immunopathological disease and enhanced lethality (26, 27) . Macrophage infection has been demonstrated in infected humans or animals (28) (29) (30) , and both types of cells are readily infected with coronaviruses after culture in vitro (24, 31, 32) .
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