Author: Lu, Yan; Jiang, Yun; Ling, Lijun; Zhang, Yunyi; Li, Hong; Chen, Daofeng
Title: Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities Document date: 2017_12_8
ID: q4r36tpw_56
Snippet: Our recent bioactivity-guided fractionation on CHCP led to the isolation of three anti-complementary homogeneous polysaccharides with CH 50 and AP 50 values not more than 0.3 mg/mL, and similar monosaccharide composition to that of CHCP (data not published). These results further confirmed that the anti-complementary polysaccharides should be the key material basis of the beneficial effects of CHCP on ALI and fever. Composed of large amount of mo.....
Document: Our recent bioactivity-guided fractionation on CHCP led to the isolation of three anti-complementary homogeneous polysaccharides with CH 50 and AP 50 values not more than 0.3 mg/mL, and similar monosaccharide composition to that of CHCP (data not published). These results further confirmed that the anti-complementary polysaccharides should be the key material basis of the beneficial effects of CHCP on ALI and fever. Composed of large amount of monosaccharides through glucosidic bonds, polysaccharides are too complex to accurately control the quality by one specific analytical method. Multiple methods were used to comprehensively characterize the structure of CHCP, including contents of carbohydrate and uronic acid, molecular weight, and monosaccharide composition.
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