Author: Zhou, Haixia; Zhao, Jincun; Perlman, Stanley
Title: Autocrine Interferon Priming in Macrophages but Not Dendritic Cells Results in Enhanced Cytokine and Chemokine Production after Coronavirus Infection Document date: 2010_10_19
ID: qg541qho_6
Snippet: MHV-induced upregulation of type I IFN, MDA5, and RIG-I in BMM is dependent on IFNAR. To begin to investigate why BMM but not BMDC produced IFN after MHV infection, we examined the levels of MDA5, since this intracellular helical sensor is required for IFN induction in BMM (24) . Basal levels of MDA5 mRNA in mock-infected BMM were approximately 2-fold higher than in BMDC ( Fig. 2A ). After infection with MHV, MDA5 levels were upregulated with sim.....
Document: MHV-induced upregulation of type I IFN, MDA5, and RIG-I in BMM is dependent on IFNAR. To begin to investigate why BMM but not BMDC produced IFN after MHV infection, we examined the levels of MDA5, since this intracellular helical sensor is required for IFN induction in BMM (24) . Basal levels of MDA5 mRNA in mock-infected BMM were approximately 2-fold higher than in BMDC ( Fig. 2A ). After infection with MHV, MDA5 levels were upregulated with similar kinetics in BMM and BMDC; however, levels in BMM were about 20 to 30 times higher than in BMDC at 24 h p.i. (Fig. 2B and C) . Similar changes in expression of a second intracellular sensor molecule, RIG-I, were also observed. RIG-I is not believed to be critical for IFN production in MHV-infected BMM, although it has an important role in cells such as oligodendrocytes (25) .
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