Author: William Binning; Aja E. Hogan-Cann; Diana Yae Sakae; Matthew Maksoud; Valeriy Ostapchenko; Mohammed Al-Onaizi; Sara Matovic; Wei-Yang Lu; Marco A. M. Prado; Wataru Inoue; Vania F. Prado
Title: Chronic hM3Dq signaling in microglia ameliorates neuroinflammation in male mice Document date: 2020_1_28
ID: ely200x3_86
Snippet: As alterations in the intracellular calcium concentration have been shown to be important for modulation of cytokine expression by microglia (Goghari et al., 2000; Hoffmann et al., 2003; McLarnon et al., 2001; Tvrdik and Kalani, 2017) , we investigated whether acute activation of hM3Dq alters microglia cytokine expression under normal conditions as well as during LPSinduced neuroinflammation. To test this, we used qPCR to measure mRNA expression .....
Document: As alterations in the intracellular calcium concentration have been shown to be important for modulation of cytokine expression by microglia (Goghari et al., 2000; Hoffmann et al., 2003; McLarnon et al., 2001; Tvrdik and Kalani, 2017) , we investigated whether acute activation of hM3Dq alters microglia cytokine expression under normal conditions as well as during LPSinduced neuroinflammation. To test this, we used qPCR to measure mRNA expression of proinflammatory cytokines in the hippocampus of CX3CR1CreER(+/-)-hM3Dq(+/-) mice that were treated with CNO or vehicle prior to receiving either LPS or saline injection (Fig. 3A) . Acute
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