Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_670
Snippet: Our study revealed that MPA had no concentration-dependent effect on the CD4 cell activation assay, with no significant difference between DMSO vehicle control (376 AE 25, mean relative fluorescence units AE SEM) and even the highest MPA concentration evaluated of 320 ng/mL (352 AE 24). Lymphocyte proliferation assays, in contrast, revealed that MPA reliably inhibited both B and T cell proliferation in a concentration-dependent manner, with an IC.....
Document: Our study revealed that MPA had no concentration-dependent effect on the CD4 cell activation assay, with no significant difference between DMSO vehicle control (376 AE 25, mean relative fluorescence units AE SEM) and even the highest MPA concentration evaluated of 320 ng/mL (352 AE 24). Lymphocyte proliferation assays, in contrast, revealed that MPA reliably inhibited both B and T cell proliferation in a concentration-dependent manner, with an IC 50 (half maximal inhibitory concentration) of between 5 and 10 ng/mL for both assays (Figure 1 ).
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