Title: 2017 ACVIM Forum Research Abstract Program Document date: 2017_6_15
ID: ri2w5iby_799
Snippet: Macrolide Pharmacokinetic evaluation of lithium chloride (LiCl), administered to healthy adult horses as an intravenous (IV) bolus, has not been reported. Nor does there exist a validated rapid procedure for determining plasma lithium (Li + ) concentrations in horses in order to monitor therapeutic levels and avoid toxicity. The goals of this study were to determine the IV bolus pharmacokinetic parameters of Li + for healthy adult horses and comp.....
Document: Macrolide Pharmacokinetic evaluation of lithium chloride (LiCl), administered to healthy adult horses as an intravenous (IV) bolus, has not been reported. Nor does there exist a validated rapid procedure for determining plasma lithium (Li + ) concentrations in horses in order to monitor therapeutic levels and avoid toxicity. The goals of this study were to determine the IV bolus pharmacokinetic parameters of Li + for healthy adult horses and compare agreement between two methods of measurement of plasma Li + concentration: spectrophotometric enzymatic assay (SEA) and inductively coupled plasma mass spectrometry (ICP-MS; reference method).
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