Author: Fuqua, Joshua L.; Hamorsky, Krystal; Khalsa, Guruatma; Matoba, Nobuyuki; Palmer, Kenneth E.
Title: Bulk production of the antiviral lectin griffithsin Document date: 2015_7_14
ID: yaqioaa5_19_1
Snippet: nt (Walwyn et al., 2015) . Most of the cost of manufacturing proteins is associated with downstream processing, specifically purification and analytics. Downstream costs were not scrutinized carefully in early economic analyses of plant-production systems and are generally estimated to account for 65% to 95% of the cost of goods. An exception may be applied if the product does not involve significant downstream processing. Consideration of upstre.....
Document: nt (Walwyn et al., 2015) . Most of the cost of manufacturing proteins is associated with downstream processing, specifically purification and analytics. Downstream costs were not scrutinized carefully in early economic analyses of plant-production systems and are generally estimated to account for 65% to 95% of the cost of goods. An exception may be applied if the product does not involve significant downstream processing. Consideration of upstream and downstream processing costs as independent variables leads to the assumption that optimization of the expression system would have little impact on the cost of goods (Fischer et al., 2013; Wilken and Nikolov, 2012) .
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