Selected article for: "different host and host immune response"
Author: D’Anna, Silvestro Ennio; Balbi, Bruno; Cappello, Francesco; Carone, Mauro; Di Stefano, Antonino
Title: Bacterial–viral load and the immune response in stable and exacerbated COPD: significance and therapeutic prospects
  • Document date: 2016_3_1
    • ID: qo3nejo9_26
    Snippet: The genetic changes probably present in COPD at different stages (severe vs mild) or having different phenotypes (frequent exacerbators vs nonfrequent) were outside the scope of the present review. Well-planned studies applying appropriate washout periods from therapeutic treatments of COPD patients in different clinical conditions are also needed for a correct quantitation of the microbiome in these different clinical states. Understanding the d.....
    Document: The genetic changes probably present in COPD at different stages (severe vs mild) or having different phenotypes (frequent exacerbators vs nonfrequent) were outside the scope of the present review. Well-planned studies applying appropriate washout periods from therapeutic treatments of COPD patients in different clinical conditions are also needed for a correct quantitation of the microbiome in these different clinical states. Understanding the dynamics of the lung microbiome in different clinical conditions and the interactions with the related endogenous host immune response will improve our knowledge of the pathologic and molecular mechanisms underlying COPD, as a consequence enabling the development of new therapeutic strategies to limit the progression of the disease.

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