Author: Sun, Ying; Xiao, ShaoBo; Wang, Dang; Luo, Rui; Li, Bin; Chen, HuanChun; Fang, LiuRong
Title: Cellular membrane cholesterol is required for porcine reproductive and respiratory syndrome virus entry and release in MARC-145 cells Document date: 2011_12_16
ID: zrsnahi7_36
Snippet: Many studies have reported that cholesterol is involved in the replication of some enveloped virus, such as Herpes simplex virus [26] , Vaccinia virus [25] , Murine coronavirus [24] , SARS-CoV [28] , Varicella-zoster virus [34] , and Pseudorabies virus [35] . The present study showed that the inhibition of PRRSV infection in vitro occurred as host cell membrane cholesterol decreased due to MβCD treatment. This effect could be counteracted by the.....
Document: Many studies have reported that cholesterol is involved in the replication of some enveloped virus, such as Herpes simplex virus [26] , Vaccinia virus [25] , Murine coronavirus [24] , SARS-CoV [28] , Varicella-zoster virus [34] , and Pseudorabies virus [35] . The present study showed that the inhibition of PRRSV infection in vitro occurred as host cell membrane cholesterol decreased due to MβCD treatment. This effect could be counteracted by the addition of exogenous cholesterol and demonstrated the importance of membrane cholesterol for PRRSV infection.
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