Author: Rosati, A; Graziano, V; De Laurenzi, V; Pascale, M; Turco, M C
Title: BAG3: a multifaceted protein that regulates major cell pathways Document date: 2011_4_7
ID: uxltqopq_11_1
Snippet: BAG1) and a stimulation of autophagy. In agreement with this hypothesis, BAG3/BAG1 protein ratio increases, concomitantly with an increase in autophagy, in an in vitro model of cell aging (replicative senescence: I90 cells) and in rodent brain neurons during aging. 75 The authors attribute BAG3 increase to oxidative stress due to the enhanced pro-oxidant milieu characteristic of aging. As this milieu enhances the occurrence of protein aggregation.....
Document: BAG1) and a stimulation of autophagy. In agreement with this hypothesis, BAG3/BAG1 protein ratio increases, concomitantly with an increase in autophagy, in an in vitro model of cell aging (replicative senescence: I90 cells) and in rodent brain neurons during aging. 75 The authors attribute BAG3 increase to oxidative stress due to the enhanced pro-oxidant milieu characteristic of aging. As this milieu enhances the occurrence of protein aggregation, BAG3-stimulated autophagy is interpreted as an adaptive response of the protein quality control system. 75
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