Author: Rosati, A; Graziano, V; De Laurenzi, V; Pascale, M; Turco, M C
Title: BAG3: a multifaceted protein that regulates major cell pathways Document date: 2011_4_7
ID: uxltqopq_16
Snippet: It is of particular interest that BAG3 deficiency can result in the loss of hematopoietic stem cells due to a defect in stem cell niche. 61 Therefore, BAG3 is required for the stem cellsupporting activity of microenvironmental cells. This finding suggests that BAG3 may also regulate the cancer stem cell-supporting activity of stromal cells in the hematopoietic and possibly in other compartments. Again, NF-kB factors could represent key targets of.....
Document: It is of particular interest that BAG3 deficiency can result in the loss of hematopoietic stem cells due to a defect in stem cell niche. 61 Therefore, BAG3 is required for the stem cellsupporting activity of microenvironmental cells. This finding suggests that BAG3 may also regulate the cancer stem cell-supporting activity of stromal cells in the hematopoietic and possibly in other compartments. Again, NF-kB factors could represent key targets of BAG3, not only for the expression of tumor cell genes that sustain cell survival, but also for the expression of stromal cells' soluble and cell surface molecules that mediate bidirectional interactions between tumor cells and their environment. 77, 78
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