Selected article for: "alternative pathway and classical pathway"
Author: Lu, Yan; Jiang, Yun; Ling, Lijun; Zhang, Yunyi; Li, Hong; Chen, Daofeng
Title: Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities
  • Document date: 2017_12_8
    • ID: q4r36tpw_31
    Snippet: CHCP was a dark brown powder and soluble in water. The total carbohydrate, uronic acid and protein contents of CHCP were 77.2172.84%, 36.6974.94% and 6.1771.93%, respectively. HPGPC analysis showed that CHCP contained one major polysaccharide and several minor ones, with molecular weight ranging from 1000 to 5000 kDa (Supporting information Fig. S1 ). GC analysis indicated that the complex macromolecules were linked by multiple monosacchrides, ma.....
    Document: CHCP was a dark brown powder and soluble in water. The total carbohydrate, uronic acid and protein contents of CHCP were 77.2172.84%, 36.6974.94% and 6.1771.93%, respectively. HPGPC analysis showed that CHCP contained one major polysaccharide and several minor ones, with molecular weight ranging from 1000 to 5000 kDa (Supporting information Fig. S1 ). GC analysis indicated that the complex macromolecules were linked by multiple monosacchrides, mainly including glucose, galactose, arabinose and rhamnose in the ratio of 3.40:2.14:1.17:1, together CHCP showed stronger inhibitory effect than heparin through classical pathway (Po0.001), while its inhibition on alternative pathway was a little weaker compared with heparin (Po0.01) (Fig. 1 ). Its CH 50 and AP 50 values were 0.09270.020 mg/mL and 0.20970.036 mg/mL (n ¼3), respectively.

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