Cassiae semen: A review of its phytochemistry and pharmacology

Dong, Xiaoxv; Fu, Jing; Yin, Xingbin; Yang, Chunjing; Zhang, Xin; Wang, Wenping; Du, Xueying; Wang, Qingling; Ni, Jian

Cassiaside C (50) 56 Torachrysone apiglucoside (17) 57 Torachrysone gentiobioside (17) 58 Torachrysone tetraglucoside (17) 59 Cassiatoroside (51) 60 Demethylflavasperone gentiobioside (17) 61 Cassialactone gentiobioside (28) 62 Torosachrysone (53) 63 Isotoralactone (53) 64 Cassialactone (53) 65 Cassiaside (71, 72) . These results were verified by a previous study, which applied an experimental hyperlipidemic rat model to investigate anthraquinone treatment (80 and 20 mg/kg, per os, for 20 days). The TC, TG and LDL-C levels were significantly reduced in a dose-dependent manner, however, the levels of HDL-C increased. Inhibition of cholesterol synthesis may be one of the underlying mechanisms involved in decreasing blood lipid levels (73) . Water-soluble polysaccharides (WSPs) from Cassiae semen markedly inhibited the activities of α-amylase and pancreatic lipase, however, protease activity increased. The results demonstrated that WSPs had the ability to bind to bile acids and reduce the absorption of cholesterol, indicating that WSPs may have potential as an effective herbal ingredient in functional food applications (74) .