Author: Lu, Yan; Jiang, Yun; Ling, Lijun; Zhang, Yunyi; Li, Hong; Chen, Daofeng
Title: Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities Document date: 2017_12_8
ID: q4r36tpw_1
Snippet: The complement system is composed of more than 30 plasma and membrane-bound proteins, and is considered to be a nonspecific host immune response. It is activated immediately after injury and to a greater degree during resuscitation 1 . However, the inappropriate activation of the complement system has been demonstrated to play a role in the pathogenesis of a wide range of auto-immune disorders, acute inflammatory diseases and tissue injuries 2,3 .....
Document: The complement system is composed of more than 30 plasma and membrane-bound proteins, and is considered to be a nonspecific host immune response. It is activated immediately after injury and to a greater degree during resuscitation 1 . However, the inappropriate activation of the complement system has been demonstrated to play a role in the pathogenesis of a wide range of auto-immune disorders, acute inflammatory diseases and tissue injuries 2,3 . C3a, C4a and C5a, the anaphylatoxins cleaved respectively from the complement components C3, C4 and C5 during complement activation, may trigger degranulation of endothelial cells, mast cells or phagocytes, and induce inflammatory responses as well as the fatal shock-like syndrome 4 . Modulation of the complement activity could be beneficial in treating various complementassociated diseases 5, 6 .
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