Selected article for: "acute respiratory and lung injury"
Author: Lu, Yan; Jiang, Yun; Ling, Lijun; Zhang, Yunyi; Li, Hong; Chen, Daofeng
Title: Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities
  • Document date: 2017_12_8
    • ID: q4r36tpw_2
    Snippet: Acute lung injury (ALI) is characterized with respiratory dysfunction, hypoxemia with presence of diffuse pulmonary infiltrates, widespread lung inflammation 7 , increased pulmonary vascular permeability and accumulation of activated neutrophils in the lung 8 . Acute respiratory distress syndrome (ARDS) is the most severe form of ALI 9 . Complement activation is an early step in ALI 3 through both the classical pathway and the alternative pathway.....
    Document: Acute lung injury (ALI) is characterized with respiratory dysfunction, hypoxemia with presence of diffuse pulmonary infiltrates, widespread lung inflammation 7 , increased pulmonary vascular permeability and accumulation of activated neutrophils in the lung 8 . Acute respiratory distress syndrome (ARDS) is the most severe form of ALI 9 . Complement activation is an early step in ALI 3 through both the classical pathway and the alternative pathway 10 . The loss of endothelial integrity in the process of ALI/ARDS also causes injured pulmonary cells to release some tissue factors or enzymes, which would lead to the initiation of complement cascade 10, 11 . A cycle of complement activation and lung injury is consequently formed. Hence, the application of complement inhibitors should be a novel treatment strategy for infectious fever and ALI.

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