Selected article for: "approach stabilize and capture stabilize"
Author: Chu, Ruiyin; Reczek, David; Brondyk, William
Title: Capture-stabilize approach for membrane protein SPR assays
  • Document date: 2014_12_8
    • ID: ueofl0wn_10
    Snippet: In conclusion, we have demonstrated the first successful use of a simple chemical cross-linking step to stabilize captured membrane proteins on Biacore chip surfaces. The resultant membrane protein surfaces remains stable allowing multiple rounds of consistent binding analyses with low pH regeneration steps. The capture-stabilize approach should provide a very useful tool for analyzing antibodies against a variety of membrane protein targets......
    Document: In conclusion, we have demonstrated the first successful use of a simple chemical cross-linking step to stabilize captured membrane proteins on Biacore chip surfaces. The resultant membrane protein surfaces remains stable allowing multiple rounds of consistent binding analyses with low pH regeneration steps. The capture-stabilize approach should provide a very useful tool for analyzing antibodies against a variety of membrane protein targets.

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