Author: Xing, Liang; Sun, Feng; Wang, Zhendong; Li, Yan; Yang, Zhifang; Wang, Fengshan; Zhai, Guangxi; Tan, Haining
Title: Characterization and bioactivity of self-assembled anti-angiogenic chondroitin sulfate-ES2-AF nanoparticle conjugate Document date: 2019_4_10
ID: x8f598x2_31
Snippet: The inhibitory effect of CS-ES2-AF on the binding capacity of VEGF to its receptor VEGFR1 (Flt-1) was determined by ELISA. 10, 30 The absorbance of the positive control well was set to 100%, and the ratio of the experimental well and the contrast well absorption values was used to express the inhibitory ability of the different experimental samples. As shown in Figure 3B , the inhibitory ability of the three experimental groups increased signific.....
Document: The inhibitory effect of CS-ES2-AF on the binding capacity of VEGF to its receptor VEGFR1 (Flt-1) was determined by ELISA. 10, 30 The absorbance of the positive control well was set to 100%, and the ratio of the experimental well and the contrast well absorption values was used to express the inhibitory ability of the different experimental samples. As shown in Figure 3B , the inhibitory ability of the three experimental groups increased significantly with increasing concentrations in a range of 5-500 μg/mL, indicating that the inhibition occurred in a concentration-dependent manner. At the same concentration, the inhibition of CS-ES2-AF was significantly better than both ES2-AF and CS&ES2-AF, indicating that the glycosylation (modification) significantly enhanced the ability of ES2-AF to inhibit the binding of VEGF to VEGFR1 (Flt-1). This was consistent with the cell proliferation experimental results mentioned earlier.
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