Clinical and laboratory profiles of hospitalized children with acute respiratory virus infection

Choi, Eunjin; Ha, Kee-Soo; Song, Dae Jin; Lee, Jung Hwa; Lee, Kwang Chul

Cases of AdV, hEV, and hRV had a greater tendency to show leukocytosis over 10,000/L when compared to other viruses (60.4%, 61.1%, and 64.8%, P<0.05). Although leukopenia less than 4,000/L was observed more with IFA, IFB (7.0%, 9.1%, P<0.05), an absolute neutrophil count less than 1,000/mL was more associated with PIV (11.9%, P<0.001). While neutrophil-dominant inflammation, represented by a neutrophil-to-lymphocyte ratio ≥3, was more associated with IFA, IFB, AdV, hRV, and hEV, lymphocyte-dominant inflammation with a neutrophil-to-lymphocyte ratio ≤1 was more associated with RSV A, RSV B, PIV, and hMPV. Monocytosis greater than 1,000/L was observed more with RSV A, RSV B, and AdV (56.2%, 62.1%, and 59.5%), while eosinophilia greater than 500/L was observed more with hRV than with other viruses (15.6%, P<0.05). Although not common, thrombocytopenia less than 100,000/L was observed more with hCV-OC43 (7.9%, P=0.000).