Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities

Lu, Yan; Jiang, Yun; Ling, Lijun; Zhang, Yunyi; Li, Hong; Chen, Daofeng

As shown in Fig. 4 , the pathogenesis of ALI resulted in significant decrease of SOD activity and marked increase of MDA content in comparison with the Sham group (Po0.001). Treatment with prednisone or CHCP at the dose of 50 and 100 mg/kg significantly Figure 2 Hemolytic assays for individual components utilizing C-depleted serum. CHCP-treated serum was mixed with various depleted sera, and the capacity of these depleted sera to restore the classical pathway hemolysis was estimated by adding sheep antibodysensitized erythrocytes. Results were expressed as hemolytic percentages. Data were listed as mean7SD, n ¼3. .001) , indicating that CHCP reduced the consumption of the complement components (Fig. 5 ).