Author: Lu, Yan; Jiang, Yun; Ling, Lijun; Zhang, Yunyi; Li, Hong; Chen, Daofeng
Title: Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities Document date: 2017_12_8
ID: q4r36tpw_52
Snippet: Hence, other choice of agents with less adverse effects is crucial to the recovery of ALI. Based on the important role of complement activation in the induction of inflammatory response in ALI/ ARDS 3, 12 , the in vivo anti-complementary activity of CHCP and its preventive effect on ALI were examined in the "two-hit" ALI rat model of ischemia/reperfusion (I/R) injury followed by LPS instillation. This "two-hit" ALI rat model had been shown to ind.....
Document: Hence, other choice of agents with less adverse effects is crucial to the recovery of ALI. Based on the important role of complement activation in the induction of inflammatory response in ALI/ ARDS 3, 12 , the in vivo anti-complementary activity of CHCP and its preventive effect on ALI were examined in the "two-hit" ALI rat model of ischemia/reperfusion (I/R) injury followed by LPS instillation. This "two-hit" ALI rat model had been shown to induce an exaggerated response for more susceptibility to lung injury 24 . I/R is believed to augment neutrophil-mediated lung injury by priming circulating neutrophils for increased superoxide production 31 . The activation of complement system is known to be necessary for the full development of inflammatory responses and tissue injuries associated with I/R in pulmonary injury 3 . Based on I/R, intratracheal instillation of LPS will induce an ideal experimental model of ALI by resulting in pulmonary injury with great BALF neutrophil infiltration 32 .
Search related documents:
Co phrase search for related documents- adverse effect and important role: 1, 2, 3, 4
- agent choice and important role: 1
- ALI experimental model and complement activation: 1
- ALI experimental model and experimental model: 1, 2, 3, 4
- ALI rat model and anti complementary activity: 1
- ALI rat model and CHCP anti complementary activity: 1
- ALI rat model and complement activation: 1
- ALI rat model and hit ALI rat model: 1
- anti complementary activity and CHCP anti complementary activity: 1, 2
- anti complementary activity and complement activation: 1, 2, 3
- anti complementary activity and complement activation important role: 1
- anti complementary activity and complement system: 1
- anti complementary activity and complement system activation: 1
- anti complementary activity and experimental model: 1
- anti complementary activity and hit ALI rat model: 1
- CHCP anti complementary activity and complement activation: 1, 2
- CHCP anti complementary activity and complement activation important role: 1
- CHCP anti complementary activity and complement system: 1
- CHCP anti complementary activity and hit ALI rat model: 1
Co phrase search for related documents, hyperlinks ordered by date