Author: Cadwell, Ken; Debnath, Jayanta
Title: Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins Document date: 2018_3_5
ID: s1qd3x1b_6_1
Snippet: NOX2, an NAD PH oxidase that generates ROS inside the phagosome. This subsequently triggers the recruitment and activation of the ATG conjugation machinery, which mediates LC3-II at the single membrane phagosome. LC3-II expedites fusion to lysosomes and degradation of the offending pathogen. Gee et al., 2011) . To date, apart from these limited targets, the broader autophagy-dependent secretome remains uncharacterized. Accordingly, recent quantit.....
Document: NOX2, an NAD PH oxidase that generates ROS inside the phagosome. This subsequently triggers the recruitment and activation of the ATG conjugation machinery, which mediates LC3-II at the single membrane phagosome. LC3-II expedites fusion to lysosomes and degradation of the offending pathogen. Gee et al., 2011) . To date, apart from these limited targets, the broader autophagy-dependent secretome remains uncharacterized. Accordingly, recent quantitative proteomic analysis of the secretome from ATG5-deficient macrophages has uncovered new leaderless proteins that may be secreted in an autophagydependent manner (Kimura et al., 2017) . However, it remains unclear from these genetic loss-of-function studies whether the observed secretory defects represent a direct versus indirect consequence of impaired autophagy.
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