Selected article for: "allele frequency and variant allele"
Author: Paquin, Ashley; Onabajo, Olusegun O.; Tang, Wei; Prokunina-Olsson, Ludmila
Title: Comparative Functional Analysis of 12 Mammalian IFN-?4 Orthologs
  • Document date: 2016_1_1
    • ID: sqxrwgif_3
    Snippet: A recently discovered type-III IFN, IFN-l4 (Prokunina-Olsson and others 2013) reviewed in (O'Brien and others 2014), can be created only in the presence of the DG allele of a dinucleotide genetic variant rs368234815-TT/DG; this variant is polymorphic in humans, but only the ancestral DG allele seems to be present in nonhuman species. The human-specific TT allele, which eliminates IFN-l4 protein by a frameshift in the first exon, appeared only 60,.....
    Document: A recently discovered type-III IFN, IFN-l4 (Prokunina-Olsson and others 2013) reviewed in (O'Brien and others 2014), can be created only in the presence of the DG allele of a dinucleotide genetic variant rs368234815-TT/DG; this variant is polymorphic in humans, but only the ancestral DG allele seems to be present in nonhuman species. The human-specific TT allele, which eliminates IFN-l4 protein by a frameshift in the first exon, appeared only 60,000 years ago (Key and others 2014) . Apparently, this event was beneficial because it was favored by positive selection, which has resulted in a rapid increase of the TT allele frequency (or a rapid loss of the DG allele) in human populations (Key and others 2014) .

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