Author: Xing, Liang; Sun, Feng; Wang, Zhendong; Li, Yan; Yang, Zhifang; Wang, Fengshan; Zhai, Guangxi; Tan, Haining
Title: Characterization and bioactivity of self-assembled anti-angiogenic chondroitin sulfate-ES2-AF nanoparticle conjugate Document date: 2019_4_10
ID: x8f598x2_50
Snippet: The VEGF/VEGFR1 (Flt-1) pathway is an important signaling pathway that can regulate the proliferation, division, and migration of vascular endothelial cells. 52 Endothelial cells can be regulated from the beginning of the signal by inhibiting the binding of VEGF to its receptor, thereby inducing endothelial cell apoptosis and migration inhibition, thus reducing the formation of vessels in tumor tissue. In this study, the main active fragment that.....
Document: The VEGF/VEGFR1 (Flt-1) pathway is an important signaling pathway that can regulate the proliferation, division, and migration of vascular endothelial cells. 52 Endothelial cells can be regulated from the beginning of the signal by inhibiting the binding of VEGF to its receptor, thereby inducing endothelial cell apoptosis and migration inhibition, thus reducing the formation of vessels in tumor tissue. In this study, the main active fragment that inhibited the binding of VEGF to its receptor was short peptide AF section. The water solubility of AF is poor due to its high content of aromatic amino acids. Therefore, AF was modified with ES2 peptide by solid-phase synthesis to improve its water solubility. Then, ES2-AF was modified with CS, a better water-soluble mucopolysaccharide, to further improve the water-solubility of ES2-AF. The water solubility of AF was significantly improved after modification, so the ability of CS-ES2-AF to inhibit the binding of VEGF to its receptor, VEGFR1, was stronger than that of ES2-AF.
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