Author: Mishra, Subodh Kumar; Shankar, Uma; Jain, Neha; Sikri, Kriti; Tyagi, Jaya Sivaswami; Sharma, Tarun Kumar; Mergny, Jean-Louis; Kumar, Amit
Title: Characterization of G-Quadruplex Motifs in espB, espK, and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets Document date: 2019_4_30
ID: qhkwn1on_10
Snippet: NMR spectroscopy is a highly reliable technique to confirm the formation of stable G4 structures by nucleic acids. 39, 40 Therefore, we examined the one-dimensional proton NMR (1D 1 H NMR) spectra of MTB-PGQs in vitro. In 1D 1 H NMR, the chemical shift signals appear between 10.5 and 12 ppm pertaining to Hoogsteen base pairing involved in G4 formation, whereas signals between 12 and 14 ppm pertain to Watson-Crick base pairing. Encouragingly, 1D 1.....
Document: NMR spectroscopy is a highly reliable technique to confirm the formation of stable G4 structures by nucleic acids. 39, 40 Therefore, we examined the one-dimensional proton NMR (1D 1 H NMR) spectra of MTB-PGQs in vitro. In 1D 1 H NMR, the chemical shift signals appear between 10.5 and 12 ppm pertaining to Hoogsteen base pairing involved in G4 formation, whereas signals between 12 and 14 ppm pertain to Watson-Crick base pairing. Encouragingly, 1D 1 H NMR spectra of MTB-PGQ1, MTB-PGQ2, and MTB-PGQ3 exhibited imino proton resonances between 10.5 and 12 ppm, and confirmed the formation of G4s by these MTB-PGQs (Figure 3 ).
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