Author: Gadsby, Naomi J.; Russell, Clark D.; McHugh, Martin P.; Mark, Harriet; Conway Morris, Andrew; Laurenson, Ian F.; Hill, Adam T.; Templeton, Kate E.
Title: Comprehensive Molecular Testing for Respiratory Pathogens in Community-Acquired Pneumonia Document date: 2016_4_1
ID: s04e6po9_33
Snippet: A recent review has noted that interventions to reduce excessive and increase effective antibiotic prescribing in hospitalized patients can have a positive impact on antimicrobial resistance, hospitalacquired infections, and clinical outcomes [45] . However, studies in the pneumonia setting have been small and either focused on atypical bacteria and viruses [46] or nonquantitative molecular detection of bacteria [30] , demonstrating 11% and 67% a.....
Document: A recent review has noted that interventions to reduce excessive and increase effective antibiotic prescribing in hospitalized patients can have a positive impact on antimicrobial resistance, hospitalacquired infections, and clinical outcomes [45] . However, studies in the pneumonia setting have been small and either focused on atypical bacteria and viruses [46] or nonquantitative molecular detection of bacteria [30] , demonstrating 11% and 67% antibiotic modification, respectively. The results of comprehensive molecular testing in our study were not available to the treating physicians due to the anonymized study protocol. However, we estimated that de-escalation and/or reduction in the number of agents might have occurred in three quarters of our CAP patients. This was based on significantly improved bacterial detection capability, high rates of broad-spectrum empirical antibiotic usage in our cohort, and knowledge of local antimicrobial resistance patterns.
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